Discovery of 7-alkyloxy- [1,2,4] triazolo[1,5-a] pyrimidine derivatives as selective positive modulators of GABAA1 and GABAA4 receptors with potent antiepileptic activity
Jun Wu, Zhipeng Hou, Yan Wang, Liping Chen, Cheng Lian, Qingfei Meng, Chaoying Zhang, Xiufen Li, Longjiang Huang, Haibo Yu
Topics & Concepts
GABAA receptorChemistryAnticonvulsantPyrimidineReceptorAllosteric regulationPharmacologyLong-term potentiationIonotropic effectStereochemistryNMDA receptorMechanism of actionNeuroscienceBiochemistryEpilepsyIn vitroPsychologyBiologyPhenothiazines and Benzothiazines Synthesis and ActivitiesNeuroscience and Neuropharmacology ResearchChemical Synthesis and Analysis