On the <i>in silico</i> and <i>in vitro</i> anticancer activity of sulfonamide chalcones: potential JNKK3 inhibitors
Jean M. F. Custódio, Andréa Felinto Moura, Manoel O. de Moraes, Caridad N. Pérez, Hamilton B. Napolitano
Abstract
Although many compound classes have been studied as JNK inhibitors, we are interested in using chalcones for this purpose. Do different groups drive to different bindings modes to JNK?
Topics & Concepts
ChemistryIn silicoSulfonamideIn vitroCombinatorial chemistryPharmacologyStereochemistryBiochemistryGeneMedicineMelanoma and MAPK PathwaysSynthesis and biological activityCytokine Signaling Pathways and Interactions