Desymmetrization of 1,3-Diones by Catalytic Enantioselective Condensation with Hydrazine
Bin‐Miao Yang, Jun Dai, Yixin Luo, Kai Kiat Lau, Yu Lan, Zhihui Shao, Yu Zhao
Abstract
1,3-diones by enantioselective intermolecular condensation. Under the catalysis by a chiral phosphoric acid, a range of readily available 1,3-diones undergo reaction with hydrazines to produce cyclic and acyclic keto-hydrazones bearing an all-carbon quaternary center in high efficiency and enantioselectivity. These compounds are also highly versatile for the preparation of multifunctional building blocks and heterocycles in excellent stereoselectivity.
Topics & Concepts
DesymmetrizationChemistryEnantioselective synthesisCatalysisHydrazine (antidepressant)Organic chemistryPhosphoric acidCondensationOrganocatalysisIntermolecular forceCondensation reactionCombinatorial chemistryStereoselectivityMoleculeChromatographyThermodynamicsPhysicsAsymmetric Synthesis and CatalysisAxial and Atropisomeric Chirality SynthesisChemical synthesis and alkaloids