Diallyl disulfide induces DNA damage and growth inhibition in colorectal cancer cells by promoting POU2F1 ubiquitination
Longzheng Xia, Jinguan Lin, Mingjing Peng, Xianjie Jiang, Qiu Peng, Shiwen Cui, Wenlong Zhang, Shizhen Li, Jiewen Wang, Linda Oyang, Shiming Tan, Zifan Hu, Nayiyuan Wu, Yanyan Tang, Xia Luo, Zongyao Ren, Yingrui Shi, Qianjin Liao, Yujuan Zhou
Abstract
were significantly mitigated by TRIM21 silencing or activating the PI3K signaling in CRC cells. Conversely, the effects of DADS were enhanced by TRIM21 over-expression or inhibiting the PI3K/AKT signaling in CRC cells. Collectively, our findings reveal a novel mechanism by which DADS suppresses the growth of CRC by promoting POU2F1 ubiquitination, and may aid in design of novel therapeutic intervention of CRC.
Topics & Concepts
UbiquitinPI3K/AKT/mTOR pathwayProtein kinase BChemistryDNA damageCancer researchDiallyl disulfideCell growthApoptosisCell biologyColorectal cancerSignal transductionCancerBiologyBiochemistryDNAGeneGeneticsGarlic and Onion StudiesCancer Mechanisms and TherapySynthesis and biological activity