Loss of a water-mediated network results in reduced agonist affinity in a β2-adrenergic receptor clinical variant
Siddhanta V. Nikte, Krushna Sonar, Aditi Tandale, Manali Joshi, Durba Sengupta
Topics & Concepts
Allosteric regulationG protein-coupled receptorAgonistTransmembrane domainReceptorPartial agonistChemistryLigand (biochemistry)Molecular dynamicsBiophysicsBiologyComputational biologyBiochemistryComputational chemistryReceptor Mechanisms and SignalingPharmacological Effects and AssaysMass Spectrometry Techniques and Applications