Arachidonic Acid 15-Lipoxygenase: Effects of Its Expression, Metabolites, and Genetic and Epigenetic Variations on Airway Inflammation
Xu Xu, Jingyun Li, Yuan Zhang, Luo Zhang
Abstract
gene, such as DNA methylation and histone modifications, have been shown to closely relate with airway inflammation. This review summarizes the role of ALOX15 in different phenotypes of asthma, chronic obstructive pulmonary disease, chronic rhinosinusitis, aspirin-exacerbated respiratory disease, and nasal polyps, suggesting new treatment strategies for these airway inflammatory diseases with complex etiology and poor treatment response.
Topics & Concepts
EpigeneticsLipoxygenaseArachidonic acidInflammationArachidonate 5-lipoxygenaseBiologyChemistryBiochemistryImmunologyEnzymeGeneAsthma and respiratory diseasesPediatric health and respiratory diseasesGenomics, phytochemicals, and oxidative stress