Radical Cyclization-Initiated Difunctionalization Reactions of Alkenes and Alkynes
Sanjun Zhi, Xiaoming Ma, Wei Zhang
Abstract
Radical reactions are powerful in the synthesis of diverse molecular scaffolds bearing functional groups. In previous review articles, we have presented 1,2-difunctionalizations, remote 1,3-, 1,4-, 1,5-, 1,6- and 1,7-difunctionalizations, and addition followed by cyclization reactions. Presented in this paper is radical cyclization followed by the second functionalization reaction. The second functionalization could be realized by atom transfer reactions, radical or transition metal-assisted coupling reactions, and reactions with neutral molecules, cationic and anionic species.
Topics & Concepts
ChemistryCationic polymerizationSurface modificationRadical cyclizationCoupling reactionRadicalCombinatorial chemistryMoleculePhotochemistryMedicinal chemistryOrganic chemistryCatalysisPhysical chemistryRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques