Excellent Repigmentation of Generalized Vitiligo with Oral Baricitinib Combined with NB-UVB Phototherapy
Xinxin Li, Yifang Sun, Juan Du, Fang Wang, Xiaolan Ding
Abstract
Vitiligo is an acquired autoimmune skin disorder, clinically characterized by distinct white macules and patches resulting from progressive melanocyte destruction. JAK-STAT pathway plays an important role in the loss of epidermal melanocytes. Baricitinib can block the JAK-STAT pathway and the downstream chemokines as a new JAK1/2 inhibitor. In this report, we describe the successful treatment of 2 patients with oral baricitinib combined with NB-UVB phototherapy, which provides a good alternative and supplementary to treat refractory vitiligo.
Topics & Concepts
VitiligoMedicineDermatologyJanus kinaseMelanocyteRefractory (planetary science)statImmunologyCancer researchSignal transductionCytokineMelanomaBiologySTAT3BiochemistryAstrobiologymelanin and skin pigmentationSkin Protection and AgingHerpesvirus Infections and Treatments