Microfluidics for personalized drug delivery
Seyed Ebrahim Alavi, Seyed Ebrahim Alavi, Sitah Alharthi, Seyedeh Fatemeh Alavi, Seyedeh Fatemeh Alavi, Seyed Zeinab Alavi, Seyed Zeinab Alavi, Gull E. Zahra, Aun Raza, Hasan Ebrahimi Shahmabadi
Abstract
This review highlights the transformative impact of microfluidic technology on personalized drug delivery. Microfluidics addresses issues in traditional drug synthesis, providing precise control and scalability in nanoparticle fabrication, and microfluidic platforms show high potential for versatility, offering patient-specific dosing and real-time monitoring capabilities, all integrated into wearable technology. Covalent conjugation of antibodies to nanoparticles improves bioactivity, driving innovations in drug targeting. The integration of microfluidics with sensor technologies and artificial intelligence facilitates real-time feedback and autonomous adaptation in drug delivery systems. Key challenges, such as droplet polydispersity and fluidic handling, along with future directions focusing on scalability and reliability, are essential considerations in advancing microfluidics for personalized drug delivery.