The exercise-induced long noncoding RNA <i>CYTOR</i> promotes fast-twitch myogenesis in aging
Martin Wohlwend, Pirkka‐Pekka Laurila, Kristine Williams, Mario Romani, Tanes Lima, Pattamaprapanont Pattawaran, Giorgia Benegiamo, Minna K. Salonen, Bernard L. Schneider, Jari Lahti, Johan G. Eriksson, Romain Barrès, Ulrik Wisløff, José B. N. Moreira, Johan Auwerx
Abstract
Exercise activates the lncRNA Cytor , which reestablishes fast-twitch muscle fibers in aged skeletal muscle, improving morphology and function.
Topics & Concepts
MyogenesisSkeletal muscleCell biologyFunction (biology)Muscle fibreLong non-coding RNARNAMedicineBiologyPhysical medicine and rehabilitationEndocrinologyGeneticsGeneCancer-related molecular mechanisms researchRNA modifications and cancerRNA Research and Splicing