Photoactivation of the cGAS-STING pathway and pyroptosis by an endoplasmic reticulum-targeting ruthenium( <scp>ii</scp> ) complex for cancer immunotherapy
Bin-Fa Liang, Shan Jiang, Yun-Shi Zhi, Zhengyin Pan, X. Su, Qin Gong, Zhendan He, Dezhong Yao, Liang He, Chenyang Li
Abstract
A cholic acid-modified ruthenium( ii ) (Ru1) photosensitizer was synthesized. Ru1 induced pyroptosis and sequentially engaged the downstream proteins p-TBK1 and p-IRF3 within the STING pathway, thus promoting the elicitation of tumor immune responses.
Topics & Concepts
PyroptosisEndoplasmic reticulumStingImmunotherapyCancer immunotherapyCancer researchCancerChemistryMedicineCell biologyApoptosisBiologyProgrammed cell deathBiochemistryInternal medicineEngineeringAerospace engineeringinterferon and immune responsesInflammasome and immune disordersToxoplasma gondii Research Studies