Interactions between host genetics and gut microbiota determine susceptibility to CNS autoimmunity
Theresa L. Montgomery, Axel Künstner, Josephine J. Kennedy, Qian Fang, Lori Asarian, Rachel Culp‐Hill, Angelo D’Alessandro, Cory Teuscher, Hauke Busch, Dimitry N. Krementsov
Abstract
Significance Increasing evidence suggests a role for the gut microbiome in autoimmune diseases, including multiple sclerosis. However, the impact of natural genetic variation in the mammalian host and other underlying mechanisms has been largely overlooked. We used a mouse model of natural genetic diversity to explore interactions between the host and the microbiome. Our results demonstrate a complex interplay between host genotype and gut microbiota in autoimmune disease, and identify a single commensal species capable of modifying disease susceptibility in a genetically susceptible host. Our studies underscore the need to consider host genetics and baseline gut microbiota composition in autoimmunity.