Identification of a Novel <i>bla</i> <sub>NDM</sub> Variant, <i>bla</i> <sub>NDM-33,</sub> in an Escherichia coli Isolate from Hospital Wastewater in China
Tao Wang, Yuan Zhou, Chunhong Zou, Zhichen Zhu, Jie Zhu, Jingnan Lv, Xiaofang Xie, Liang Chen, Siqiang Niu, Hong Du
Abstract
Our study described a novel NDM-33 variant from an E. coli strain isolated from hospital sewage, where it was associated with human disease and antibiotic exposure. Importantly, hospital sewage was increasingly considered to be related to CRE hosts. Pathogens were transmitted from reservoirs through direct and indirect contact, ingestion, and inhalation of contaminated water or aerosols. In addition, under the selective pressure of antibiotics, NDM variants will become the main strain in the hospital water system and evolve into high virulence and high resistance. The monitoring of NDM mutants is of great significance for preventing and controlling the evolution of superbugs.