Synthesis of novel isoxazole functionalized pyrazolo[3,4‐<i>b</i>]pyridine derivatives; their anticancer activity
Sampath Ravula, Ramana Reddy Bobbala, Balakrishna Kolli
Abstract
Abstract A series of novel isoxazole functionalized pyrazolo[3,4‐b]pyridine derivatives 5a‐n were prepared, respectively, initiated from 6‐thiophenyl‐4‐(trifluoromethyl)‐1 H ‐pyrazolo[3,4‐ b ]pyridin‐3‐amine 3 through selective N ‐propargylation, and these N ‐propargylated compounds 4 were cyclized with aryloximes by using of sodium hypochlorite, and obtained the title products 5a‐n . All the final products 5a‐n were submitted for anticancer activity against four cancer cell lines such as “HeLa—cervical cancer (CCL‐2); COLO 205—colon cancer (CCL‐222); HepG2—liver cancer (HB‐8065); MCF7—breast cancer (HTB‐22)”; Compounds 5c , 5d , and 5h are found to have more prominent anticancer activity at micro molar concentration.