Primary and Acquired Resistance against Immune Check Inhibitors in Non-Small Cell Lung Cancer
Qinying Sun, Xiangzhen Wei, Zhong Lin Wang, Yan Zhu, Weiying Zhao, Yuchao Dong
Abstract
Immune checkpoint inhibitors have emerged as the treatment landscape of advanced non-small cell lung cancer (NSCLC) in recent years. However, approximately 80% of NSCLC patients do not benefit from ICIs due to primary resistance (no initial response) or acquired resistance (tumor relapse after an initial response). In this review, we highlight the mechanisms of primary and secondary resistance. Furthermore, we provide a future direction of the potential predictive biomarkers and the tumor microenvironmental landscape and suggest treatment strategies to overcome these mechanisms.
Topics & Concepts
Lung cancerAcquired resistanceMedicineImmune systemPrimary (astronomy)Primary tumorImmunotherapyCancer researchOncologyResistance (ecology)CancerImmunologyInternal medicineBiologyMetastasisEcologyPhysicsAstronomyCancer Immunotherapy and BiomarkersLung Cancer Treatments and MutationsFerroptosis and cancer prognosis