Drug-Drug Interactions at Organic Cation Transporter 1
Shiwei Zhou, Sujuan Zeng, Yan Shu
Abstract
The interaction between drugs and various transporters is one of the decisive factors that affect the pharmacokinetics and pharmacodynamics of drugs. The organic cation transporter 1 (OCT1) is a member of the Solute Carrier 22A (SLC22A) family that plays a vital role in the membrane transport of organic cations including endogenous substances and xenobiotics. This article mainly discusses the drug-drug interactions (DDIs) mediated by OCT1 and their clinical significance.
Topics & Concepts
Organic cation transport proteinsDrugTransporterPharmacologyPharmacodynamicsSolute carrier familyXenobioticPharmacokineticsChemistryMedicineBiochemistryEnzymeGeneDrug Transport and Resistance MechanismsPharmacological Effects and Toxicity StudiesAmino Acid Enzymes and Metabolism