Organocatalytic site- and stereoselective 1,6-additions of <i>N</i>-aryl-3-oxobutanamides to propargylic aza-<i>p</i>-quinone methides
Fushuai Li, Xuling Chen, Shuai Liang, Zhenyan Shi, Pengfei Li, Wenjun Li
Abstract
A chiral phosphoric acid catalyzed site-selective 1,6-conjugate addition of <italic>N</italic>-aryl-3-oxobutanamides to <italic>in situ</italic> formed propargylic aza-<italic>p</italic>-quinone methides from propargylic alcohols has been established for the first time.
Topics & Concepts
ChemistryArylStereoselectivityQuinoneConjugatePhosphoric acidStereochemistryMedicinal chemistryOrganic chemistryCatalysisMathematicsAlkylMathematical analysisSynthesis of Indole DerivativesCarbohydrate Chemistry and SynthesisChemical Synthesis and Reactions