Development of an Effective Monoclonal Antibody against Heroin and Its Metabolites Reveals Therapies Have Mistargeted 6-Monoacetylmorphine and Morphine over Heroin
Jinny Claire Lee, Lisa M. Eubanks, Bin Zhou, Kim D. Janda
Abstract
tests revealed monoclonal antibody 11D12 as the optimal therapeutic and provided crucial insights into the key chemical species to target for blunting heroin's psychoactive and lethal effects. These findings offer clarification into the problematic attempts of therapeutics targeting heroin's metabolites and provide a path forward for future heroin immunopharmacotherapy development.
Topics & Concepts
HeroinMorphinePharmacologyOpioidDrugMedicineMonoclonal antibodyAdverse effectAntibodyImmunologyInternal medicineReceptorNeuropeptides and Animal PhysiologyReceptor Mechanisms and SignalingMonoclonal and Polyclonal Antibodies Research