Enantioselective synthesis of hydantoins by chiral acid-catalysed condensation of glyoxals and ureas
Sushant Aryal, Christopher A. Hone, Matthew I. J. Polson, Daniel J. Foley
Abstract
The paper describes the enantioselective synthesis of 5-monosubstituted hydantoins via chiral phosphoric acid-catalysed condensation of glyoxals and ureas at room temperature.
Topics & Concepts
Enantioselective synthesisCondensationChemistryCombinatorial chemistryStereochemistryOrganic chemistryCatalysisThermodynamicsPhysicsChemical Synthesis and AnalysisAsymmetric Synthesis and CatalysisCarbohydrate Chemistry and Synthesis