Local Administration of Ginkgolide B Using a Hyaluronan-Based Hydrogel Improves Wound Healing in Diabetic Mice
Limei Wang, Kedi Xia, Lu Han, Min Zhang, Jihuan Fan, Liu Song, Anqi Liao, Wenyu Wang, Jianfeng Guo
Abstract
for local administration of GB to the full-thickness wounds of diabetic mice. The resultant hydrogel formulation (HA-GB) resulted in the reduction of inflammation, the enhancement of re-epithelialization and angiogenesis, and the modulation of collagens from type III to type I, significantly promoting the healing outcome as compared with a commercially available wound dressing product (INTRASITE Gel). This study confirms a great therapeutic promise of HA-GB for the chronic wounds of diabetic patients.
Topics & Concepts
Wound healingHyaluronic acidPharmacologyAdministration (probate law)ChemistryMedicineSurgeryAnatomyPolitical scienceLawWound Healing and TreatmentsGinkgo biloba and Cashew ApplicationsNeurological Disease Mechanisms and Treatments