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Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering

Edward P. Harvey, Zachary J. Hauseman, Daniel T. Cohen, T.J. Rettenmaier, Susan Lee, Annissa J. Huhn, Thomas E. Wales, Hyuk‐Soo Seo, James Luccarelli, Catherine E. Newman, Rachel M. Guerra, Gregory H. Bird, Sirano Dhe‐Paganon, John R. Engen, James A. Wells, Loren D. Walensky

2020Cell chemical biology37 citationsDOIOpen Access PDF

Topics & Concepts

TetheringDisulfide bondCovalent bondChemistryIdentification (biology)Computational biologyCell biologyBiochemistryBiologyOrganic chemistryBotanyCell death mechanisms and regulationPhagocytosis and Immune RegulationRNA Interference and Gene Delivery
Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering | Litcius