Nuclear-Encoded lncRNA MALAT1 Epigenetically Controls Metabolic Reprogramming in HCC Cells through the Mitophagy Pathway
Yijing Zhao, Lei Zhou, Hui Li, Tingge Sun, Wen Xue, Xueli Li, Ying Meng, Yán Li, Mengmeng Liu, Shanshan Liu, Su‐Jeong Kim, Jialin Xiao, Lingyu Li, Songling Zhang, Wei Li, Pinchas Cohen, Andrew R. Hoffman, Ji‐Fan Hu, Jiuwei Cui
Abstract
functions as a critical epigenetic player in the regulation of mitochondrial metabolism of hepatoma cells, laying the foundation for further clarifying the roles of lncRNAs in tumor metabolic reprogramming.
Topics & Concepts
BiologyMitophagyDNAJA3Mitochondrial DNAMitochondrionCell biologyEpigeneticsmitochondrial fusionHSPA9DNA methylationCancer researchMolecular biologyGeneticsGeneApoptosisGene expressionAutophagyPeptide sequenceCancer-related molecular mechanisms researchRNA modifications and cancerMitochondrial Function and Pathology