NIR light-triggered peroxynitrite anion production <i>via</i> direct lanthanide-triplet photosensitization for enhanced photodynamic therapy
Xi Xiao, Bingzhu Zheng, Qiang Zheng, Zijie Lu, Dong Cen, Xiujun Cai, Xiang Li, Renren Deng
Abstract
, leading to drastically promoted cancer cell apoptosis and tumor growth inhibition. This study establishes a new apoptosis-inducing PDT agent, which is potentially active in drug resistant malignancies.
Topics & Concepts
PeroxynitritePhotodynamic therapyReactive oxygen speciesLanthanideNitric oxideChemistryPhoton upconversionS-NitrosoglutathionePhotochemistryPeryleneSinglet oxygenBiophysicsMaterials scienceSuperoxideIonOxygenBiochemistryOrganic chemistryBiologyMoleculeEnzymeGlutathioneNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisAdvanced biosensing and bioanalysis techniques