Dapagliflozin protects heart function against type-4 cardiorenal syndrome through activation of PKM2/PP1/FUNDC1-dependent mitophagy
Yang Shen, Xiaojie Peng, Haizhe Ji, Wei Gong, Hang Zhu, Jin Wang
Topics & Concepts
MitophagyDephosphorylationPKM2MitochondrionGene knockdownBiologyCell biologyIn vivoPharmacologyKnockout mouseGlycolysisAutophagyPhosphataseApoptosisPhosphorylationBiochemistryPyruvate kinaseEnzymeReceptorGeneticsPancreatic function and diabetesAutophagy in Disease and TherapyMetabolism, Diabetes, and Cancer