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Discovery of substituted benzyloxy-benzylamine inhibitors of acetyltransferase Eis and their anti-mycobacterial activity

Allan H. Pang, Keith Green, Nishad Thamban Chandrika, Atefeh Garzan, Ankita Punetha, Selina Y. L. Holbrook, Melisa J. Willby, James E. Posey, Oleg V. Tsodikov, Sylvie Garneau‐Tsodikova

2022European Journal of Medicinal Chemistry17 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryMycobacterium tuberculosisAcetyltransferaseBenzylamineAminoglycosideMechanism of actionNon-competitive inhibitionBiochemistryEnzymePharmacologyAcetylationTuberculosisAntibioticsIn vitroBiologyGenePathologyMedicineMedicinal chemistryTuberculosis Research and EpidemiologyMycobacterium research and diagnosisCancer therapeutics and mechanisms
Discovery of substituted benzyloxy-benzylamine inhibitors of acetyltransferase Eis and their anti-mycobacterial activity | Litcius