Genetic and pharmacological targeting of GSDMD ameliorates systemic inflammation in macrophage activation syndrome
Shunli Tang, Changyi Yang, Sheng Li, Yuwei Ding, Dingxian Zhu, Shuni Ying, Chuanyin Sun, Yu Shi, Jianjun Qiao, Hong Fang
Topics & Concepts
Macrophage activation syndromeMedicineHepatosplenomegalyInflammationImmunologyCytokine stormAnakinraArthritisInternal medicineDiseaseInfectious disease (medical specialty)Coronavirus disease 2019 (COVID-19)Autoimmune and Inflammatory Disorders ResearchInflammasome and immune disordersIL-33, ST2, and ILC Pathways