Facile Synthesis of γ‐Ketonitriles in Water via C(sp<sup>2</sup>)–H Activation of Aromatic Aldehydes over Cu@g‐C<sub>3</sub>N<sub>4</sub> under Visible‐Light
K. Vijai, Fooleswar Verma, Smita R. Bhardiya, Harendra Sheshma, Ankita Rai, Manorama Singh
Abstract
A facile C(sp 2 )–H activation of aldehyde under visible‐light conditions using Cu@g‐C 3 N 4 as photocatalyst and water as solvent is reported. The envisaged method involves photocatalytic intermolecular Stetter reaction using differently substituted aldehydes and acrylonitrile to produce various γ‐keto nitriles in good to excellent yield (80–95 %) and 4–10 h at r.t. Operational simplicity, ambient reaction conditions, visible‐light condition, and application of the Cu@g‐C 3 N 4 as photocatalyst make the envisaged protocol an efficient and highly green alternative to the existing methods for synthesis of γ‐keto nitriles.
Topics & Concepts
ChemistryAldehydePhotocatalysisAcrylonitrileVisible spectrumYield (engineering)SolventPhotochemistryIntermolecular forceNitrileCatalysisOrganic chemistryMoleculePhysicsMaterials scienceMetallurgyPolymerOptoelectronicsCopolymerCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesRadical Photochemical Reactions