PDE5 and PDE10 inhibition activates cGMP/PKG signaling to block Wnt/β-catenin transcription, cancer cell growth, and tumor immunity
Gary A. Piazza, Antonio Ward, Xi Chen, Yulia Maxuitenko, Alexander B. Coley, Nada S. Aboelella, Donald J. Buchsbaum, Michael R. Boyd, Adam B. Keeton, Gang Zhou
Topics & Concepts
SulindacWnt signaling pathwayPhosphodiesterasePharmacologyCell growthCancer cellColorectal cancerCancerCancer researchMedicineSignal transductionChemistryBiologyCell biologyInternal medicineEnzymeBiochemistryNonsteroidalPhosphodiesterase function and regulationInflammatory mediators and NSAID effectsMast cells and histamine