Synthesis and biological evaluation of novel isoxazole-piperazine hybrids as potential anti-cancer agents with inhibitory effect on liver cancer stem cells
Kübra İbiş, Esra Nalbat, Burcu Çalışkan, Deniz Kahraman, Rengül Çetin-Atalay, Erden Banoğlu
Topics & Concepts
Cancer stem cellChemistryIsoxazoleHomeobox protein NANOGStem cellCancer researchCancer cellCell cultureCytotoxicityCell growthLiver cancerApoptosisCancerCell biologyInduced pluripotent stem cellHepatocellular carcinomaBiochemistryIn vitroBiologyEmbryonic stem cellStereochemistryGeneticsGeneCancer-related Molecular PathwaysCancer therapeutics and mechanismsPI3K/AKT/mTOR signaling in cancer