Autoimmunity after Coronavirus Disease 2019 (COVID-19) Vaccine: A Case of Acquired Hemophilia A
Scott Farley, Robert Ousley, Nicholas Van Wagoner, Fernando Bril
Abstract
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been strongly associated with immune-mediated reactions, including the development of autoimmune disorders.[1] It is theorized that the spike protein S1 of SARS-CoV-2 may be responsible for this phenomenon by means of molecular mimicry.[2] Emerging data also suggest a link between coronavirus disease 2019 (COVID-19) vaccination and development of various autoimmune conditions ranging from autoimmune hepatitis to immune thrombocytopenia (ITP).[3] [4] This is not a new phenomenon as other vaccines are also associated with immunologic adverse effects, such as Guillain–Barre syndrome, ITP, or vasculitis.[5]