53BP1–shieldin-dependent DSB processing in BRCA1-deficient cells requires CST–Polα–primase fill-in synthesis
Zachary Mirman, Nanda Kumar Sasi, Ashleigh King, J. Ross Chapman, Titia de Lange
Topics & Concepts
Cell biologyDNAHomologous recombinationMutantChemistryEffectorMolecular biologyTelomerePolymeraseMutationBiophysicsFunction (biology)BiologyDNA polymerasePrimaseSuppressorCell cultureHEK 293 cellsCellPlasma protein bindingDNA-binding proteinChromosomeDNA Repair MechanismsPARP inhibition in cancer therapyBRCA gene mutations in cancer