Self-sacrificial MOFs for ultra-long controlled release of bisphosphonate anti-osteoporotic drugs
Maria Vassaki, Konstantinos E. Papathanasiou, Chrystalleni Hadjicharalambous, Daphne Chandrinou, Petri Turhanen, Duane Choquesillo‐Lazarte, Konstantinos D. Demadis
Abstract
) and several anti-osteoporosis bisphosphonate drugs (etidronate, pamidronate, alendronate and neridronate), as the organic linkers. These materials have been synthesized, structurally characterized, and studied for the self-sacrificial release (by pH-driven dissolution) of the bisphosphonate active ingredient. They exhibit variable release rates and final % release, depending on the actual structure of the metal-bisphosphonate material. Their cytotoxicity profiles match those of the active ingredients.
Topics & Concepts
BisphosphonateNanotechnologyChemistryOsteoporosisPharmacologyMaterials scienceMedicineInternal medicineMetal-Organic Frameworks: Synthesis and ApplicationsBone health and treatmentsNanoplatforms for cancer theranostics