Two mixed valence diruthenium(<scp>ii</scp>,<scp>iii</scp>) isomeric complexes show different anticancer properties
Elisabetta Barresi, Iogann Tolbatov, Tiziano Marzo, Elisa Zappelli, Alessandro Marrone, Nazzareno Re, Alessandro Pratesi, Claudia Martini, Sabrina Taliani, Federico Da Settimo, Diego La Mendola
Abstract
In this paper it is demonstrated that the nature of the ligands of two Ru2(ii,iii) paddlewheel complexes dramatically affects the overall anticancer properties in cells. Herein, the complex [Ru2(EB776)4Cl] was found to be more active against a glioblastoma model with respect to its isomer [Ru2(EB106)4Cl]. These different effects depend on the steric hindrance, on the allowed conformations of the complexes and on the presence of hydrophilic regions in [Ru2(EB776)4Cl], which overall lead to a lower "steric protection".
Topics & Concepts
ChemistryValence (chemistry)StereochemistryOrganic chemistryMetal complexes synthesis and propertiesOrganometallic Complex Synthesis and CatalysisMagnetism in coordination complexes