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Synthesis of chiral difluoromethyl cyclopropanes through desymmetric difluoromethylation of cyclopropenes enabled by enantioselective copper catalysis

Decai Ding, Su Chen, Lingfeng Yin, Wei‐Ting Ou, Jeanette A. Krause, Mu‐Jeng Cheng, Wei Liu

2025Nature Synthesis12 citationsDOIOpen Access PDF

Topics & Concepts

Enantioselective synthesisCatalysisCopperChemistryCombinatorial chemistryOrganic chemistryFluorine in Organic ChemistryCyclopropane Reaction MechanismsCarbon dioxide utilization in catalysis
Synthesis of chiral difluoromethyl cyclopropanes through desymmetric difluoromethylation of cyclopropenes enabled by enantioselective copper catalysis | Litcius