A novel porous interbody fusion cage modified by microarc oxidation and hydrothermal treatment technology accelerate osseointegration and spinal fusion in sheep
Jiang Sun, Shanshan Liu, Da Zou, Renhua Ni, Chongbin Wei, Hao Wang, Weishi Li
Abstract
studies have confirmed the positive effects of characteristic micro/nano morphology and hydrophilicity of the coating formed after surface treatment on the adhesion, proliferation, and osteogenic differentiation of osteoblast precursor cells. Furthermore, the MAO + HT treated interbody cage showed a closer integration with the surrounding bone tissue, improved kinetic stability of the implanted segment, and significantly reduced incidence of fusion failure during the early postoperative period, which indicated that such a surface modification strategy is applicable to the biomechanical and biological microenvironment of the intervertebral space.
Topics & Concepts
CageOsseointegrationHydrothermal circulationFusionPorosityMaterials scienceSpinal fusionChemical engineeringComposite materialImplantMedicineEngineeringSurgeryStructural engineeringLinguisticsPhilosophyBone Tissue Engineering MaterialsOrthopaedic implants and arthroplastySpine and Intervertebral Disc Pathology