Paramyxovirus-Like Particles as Protein Delivery Vehicles
Santosh Panthi, Phuong Tieu Schmitt, F. Jeffrey Lorenz, Brent Stanfield, Anthony P. Schmitt
Abstract
Therapeutic proteins including transcription factors and genome editors have enormous clinical potential but are currently limited in part due to the challenges of safely and efficiently delivering these proteins to the interiors of target cells. Here, we have developed a new strategy for protein delivery based on manipulation of paramyxovirus genome packaging interactions.
Topics & Concepts
BiologyVirus-like particleCell biologyVirusEpitopeViral matrix proteinVirologyMolecular biologyAntibodyBiochemistryGeneGeneticsRecombinant DNAVirology and Viral DiseasesVirus-based gene therapy researchViral Infections and Immunology Research