Phosphodiesterases PDE2A and PDE10A both change mRNA expression in the human brain with age, but only PDE2A changes in a region-specific manner with psychiatric disease
Reagan Farmer, Steven D. Burbano, Neema S. Patel, Angelo Sarmiento, Abigail J. Smith, Michy P. Kelly
Topics & Concepts
StriatumPDE10AHippocampusNeuroscienceParahippocampal gyrusIn situ hybridizationPhosphodiesteraseAnterior cingulate cortexCortex (anatomy)BiologyMedicineInternal medicineMessenger RNADopamineEnzymeGeneticsGeneCognitionTemporal lobeBiochemistryEpilepsyPhosphodiesterase function and regulationBipolar Disorder and TreatmentReceptor Mechanisms and Signaling