Design of foldable, responsively drug-eluting polyacrylic intraocular lens bulk materials for prevention of postoperative complications
Yueze Hong, Haoyu Zou, Yulin Hu, Fan Fei, Lin Liang, Dong Liu, Yuemei Han, Quankui Lin
Abstract
An anti-proliferative drug was conjugated into bulk material via Schiff base bond to construct a pH-responsive drug-eluting IOL. The pH-responsive drug-eluting IOL can effectively prevent posterior capsular opacification after implantation.
Topics & Concepts
Intraocular lensDrug deliveryAcrylateIn vivoDrugLens (geology)Materials scienceMethacrylateCataract surgeryOphthalmologyBiomedical engineeringMedicinePharmacologyNanotechnologyOpticsMonomerComposite materialPolymerPhysicsBiologyBiotechnologyIntraocular Surgery and LensesOcular Surface and Contact LensCorneal surgery and disorders