Direct Amino-α-C–H Heteroarylation of Amides under Electrochemical Conditions
Congcong Qiang, Tan Zhang, Zhaoyue Feng, Ping Liu, Peipei Sun
Abstract
An electrochemical hydrogen atom transfer (HAT) strategy for the direct amino-α-C–H heteroarylation of amides is described. The cheap TMSN 3 acts as a hydrogen atom transfer reagent. A series of heteroarenes including quinoxalin-2(1 H )-ones, 4-methylquinoline, isoquinoline, 2-methylquinoxaline, benzothiazole, etc., and various readily available amides/lactams were suitable. The reaction has the characteristics of a wide range of substrates, good regioselectivity, chemical oxidant-free conditions, etc.
Topics & Concepts
BenzothiazoleChemistryReagentRegioselectivityHydrogen atomIsoquinolineElectrochemistryCombinatorial chemistryOrganic chemistryCatalysisGroup (periodic table)Physical chemistryElectrodeCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsAsymmetric Hydrogenation and Catalysis