Synergetic catalysis of Se and Cu allowing diethoxylation of halomethylene ketones using O<sub>2</sub> as the mild oxidant
Zhicheng Cao, Xin Deng, Chao Chen, Yonghong Liu, Lei Yu, Xuefeng Jiang
Abstract
Catalyzed by PhSe(O)OH/Cu(OAc)<sub>2</sub>, sp<sup>3</sup>-C–H alkylation of bromomethylene ketones produced useful α-carbonyl acetals under mild conditions. Bromo-containing substrates could release HBr during the reaction, avoiding the use of acidic additives.
Topics & Concepts
CatalysisAlkylationChemistryMedicinal chemistryOrganic chemistryOrganoselenium and organotellurium chemistryVanadium and Halogenation ChemistrySulfur-Based Synthesis Techniques