CXCL12-mediated monocyte transmigration into brain perivascular space leads to neuroinflammation and memory deficit in neuropathic pain
Chun-Lin Mai, Zhi Tan, Yanan Xu, Jing-Jun Zhang, Zhenhua Huang, Dong Wang, Hui Zhang, Wen-Shan Gui, Jun Zhang, Zhenjia Lin, Ying-Tong Meng, Wei Xiao, Ying-Tao Jie, Peter M. Grace, Long‐Jun Wu, Li‐Jun Zhou, Xian‐Guo Liu
Abstract
CXCL12-mediated monocyte recruitment into the perivascular space is critical for neuroinflammation and the resultant cognitive impairment in neuropathic pain.
Topics & Concepts
NeuroinflammationSNiGliosisNeuropathic painMedicinePerivascular spaceNeuNInflammationChemokineNeuroscienceCognitive declineHippocampal formationMonocyteImmunostainingProinflammatory cytokineImmunologyPharmacologyPathologyPsychologyInternal medicineImmunohistochemistryChemistryDementiaAcid hydrolysisBiochemistryHydrolysisDiseasePain Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration MechanismsNerve injury and regeneration