Mn2+ Directly Activates cGAS and Structural Analysis Suggests Mn2+ Induces a Noncanonical Catalytic Synthesis of 2′3′-cGAMP
Zhen Zhao, Zhixing Ma, Bo Wang, Yukun Guan, Xiao‐Dong Su, Zhengfan Jiang
Abstract
as a cGAS activator that initiates noncanonical 2'3'-cGAMP synthesis.
Topics & Concepts
ChemistryStereochemistryDNACatalysisActivator (genetics)MoietyCofactorCytosolCell biologyBiochemistryReceptorEnzymeBiologyinterferon and immune responsesRNA Research and SplicingRNA modifications and cancer