Accelerating PERx reaction enables covalent nanobodies for potent neutralization of SARS-CoV-2 and variants
Bingchen Yu, Shanshan Li, Takako Tabata, Nanxi Wang, Li Cao, G. Renuka Kumar, Wei Sun, Jun Liu, Mélanie Ott, Lei Wang
Topics & Concepts
Covalent bondChemistryNeutralizationPotencySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Covalent bindingCombinatorial chemistryCoronavirus disease 2019 (COVID-19)VirologyBiophysicsStereochemistryBiochemistryVirusBiologyIn vitroMedicinePathologyDiseaseOrganic chemistryInfectious disease (medical specialty)SARS-CoV-2 and COVID-19 ResearchBacteriophages and microbial interactionsMonoclonal and Polyclonal Antibodies Research