Catalytic Asymmetric Isomerization of (Homo)Allylic Alcohols: Recent Advances and Challenges
Xue‐Xin Zhang, Ying Zhang, Ling Liao, Yang Gao, Heng E. M. Su, Jin‐Sheng Yu
Abstract
Abstract Catalytic asymmetric isomerization of allylic or homoallylic alcohols into synthetically useful carbonyl compounds is a redox‐neutral and 100 % atom‐economic transformation, which is of great interest and has gained increasing attention from both academic and industry. This minireview summarizes the advances in catalytic enantioselective isomerization and it involved tandem reactions over the past five years, also discusses their advantages and limitations, and expounds the synthetic chances still open for further development.
Topics & Concepts
IsomerizationAllylic rearrangementEnantioselective synthesisCatalysisAtom economyChemistryCombinatorial chemistryOrganic chemistrySynthetic Organic Chemistry MethodsN-Heterocyclic Carbenes in Organic and Inorganic ChemistryAsymmetric Hydrogenation and Catalysis