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WP1066, a small molecule inhibitor of STAT3, chemosensitizes paclitaxel-resistant ovarian cancer cells to paclitaxel by simultaneously inhibiting the activity of STAT3 and the interaction of STAT3 with Stathmin

Jun Yang, Nanjing Li, Xinyu Zhao, Wenhao Guo, Yang Wu, Chunlai Nie, Yuan Zhu

2024Biochemical Pharmacology22 citationsDOI

Topics & Concepts

PaclitaxelStathminOvarian cancerSTAT3Cancer researchCancer cellMicrotubuleChemistryCancerBiologyPhosphorylationMedicineCell biologyInternal medicineCytokine Signaling Pathways and InteractionsCancer Mechanisms and TherapyCancer-related Molecular Pathways
WP1066, a small molecule inhibitor of STAT3, chemosensitizes paclitaxel-resistant ovarian cancer cells to paclitaxel by simultaneously inhibiting the activity of STAT3 and the interaction of STAT3 with Stathmin | Litcius