Ultrasensitive detection of microRNAs based on click chemistry-terminal deoxynucleotidyl transferase combined with CRISPR/Cas12a
Xue Li, Xiaoyu Liu, Jiaqi Wei, Shengjun Bu, Zhongyi Li, Zhuo Hao, Wenhui Zhang, Jiayu Wan
Topics & Concepts
CRISPRNucleic acidTerminal deoxynucleotidyl transferaseMolecular beaconmicroRNABiosensorComputational biologyLocked nucleic acidChemistryDNAMolecular biologyClick chemistryBiologyCombinatorial chemistryOligonucleotideBiochemistryGeneTUNEL assayApoptosisAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryCRISPR and Genetic Engineering