The Yin and Yang of epigenetics in the field of nanoparticles
Elettra Musolino, Christina Pagiatakis, Simone Serio, Marina Borgese, Federica Gamberoni, Rosalba Gornati, Giovanni Bernardini, Roberto Papait
Abstract
, cancers, neurological disorders and cardiovascular diseases). For many of these diseases, epigenetic therapies have been proposed, whose application is however limited by the toxicity of epigenetic drugs. In this review, we will analyze two aspects of epigenetics in the field of NPs: the first is the role that epigenetics play in mediating nanotoxicity, and the second is the possibility of using NPs for delivery of "epi-drugs" to overcome their limitations. We aim to stimulate discussion among specialists, specifically on the potential contribution of epigenetics to the field of NPs, and to inspire newcomers to this exciting technology.