Iridium-catalyzed enantioselective olefinic C(sp<sup>2</sup>)–H allylic alkylation
Rahul Sarkar, Santanu Mukherjee
Abstract
generated cyclometalated Ir(i)/phosphoramidite complex, makes use of the latent enolate character of an α,β-unsaturated carbonyl compound, namely coumalate ester, to introduce an allyl group at its α-position in a branched-selective manner in moderate to good yield with good to excellent enantioselectivities (up to 98 : 2 er).
Topics & Concepts
Enantioselective synthesisIridiumTsuji–Trost reactionAllylic rearrangementCatalysisChemistryAlkylationLewis acids and basesMedicinal chemistryStereochemistryOrganic chemistryAsymmetric Hydrogenation and CatalysisAsymmetric Synthesis and CatalysisCatalytic C–H Functionalization Methods