An injectable double network hydrogel with hemostasis and antibacterial activity for promoting multidrug-resistant bacteria infected wound healing
Zibo Zhang, Jiadong Guo, Yuxiang He, Jinzhi Han, Mingmao Chen, Yunquan Zheng, Shenghang Zhang, Shaobin Guo, Xianai Shi, Jianming Yang
Abstract
results demonstrated that the hydrogel can completely heal MRSA-infected wound in rats within 15 days, through inhibiting the growth of bacteria, accelerating skin tissue reepithelialization, collagen deposition, and angiogenesis, as well as adjusting the expression of CD31, α-SMA, and TNF-α. The findings of this study suggest that the presented hydrogel could enhance multidrug-resistant bacteria infected wound healing and mitigate antimicrobial resistance.
Topics & Concepts
Wound healingHemostasisMicrobiologySelf-healing hydrogelsAntimicrobialChemistryBiofilmBacteriaAntimicrobial peptidesAntibioticsIn vivoMultiple drug resistanceMedicineBiologyImmunologySurgeryOrganic chemistryGeneticsBiotechnologyWound Healing and TreatmentsAntimicrobial agents and applicationsSurgical Sutures and Adhesives