Synthesis of Pyridothiazepines via a 1,5‐Dipolar Cycloaddition Reaction between Pyridinium 1,4‐Zwitterionic Thiolates and Activated Allenes
Bin Cheng, Xinping Zhang, Hui Li, Yixuan He, Yun Li, Haiyan Sun, Taimin Wang, Hongbin Zhai
Abstract
Abstract The synthesis of pyridothiazepines has been achieved via a 1,5‐dipolar cycloaddition reaction between pyridinium 1,4‐zwitterionic thiolates and activated allenes conducted under thermal conditions. Meanwhile, a ring‐contraction reaction of the resulting pyridothiazepine derivatives via the extrusion of 3‐thioxoacrylates has also been described. magnified image
Topics & Concepts
ChemistryPyridiniumCycloaddition1,3-Dipolar cycloadditionZwitterionExtrusionContraction (grammar)Polymer chemistryCombinatorial chemistryOrganic chemistryCatalysisMoleculeMedicineMetallurgyMaterials scienceInternal medicineSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization MethodsCyclopropane Reaction Mechanisms